Description
NNMT inhibitor investigated for metabolic and anti-obesity effects
5-Amino-1MQ is a small-molecule inhibitor of NNMT, developed to boost NAD+ levels, increase energy expenditure, and reduce adipocyte size. Explored for its role in enhancing metabolic efficiency by promoting greater energy usage and stimulating fat-burning processes. Studies indicate it may help improve insulin sensitivity and glucose control, relevant for metabolic disorders and obesity studies. Through its impact on NAD+ pathways, contributes to healthier mitochondrial function and cellular energy production.
References
- Dimet-Wiley A, et al. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Sci Rep. 2022;12(1):484. PMID: 35013352 | DOI: 10.1038/s41598-021-03670-5
- Akar S, et al. Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells. J Obstet Gynaecol. 2021;41(8):1240-1245. PMID: 33645410 | DOI: 10.1080/01443615.2020.1854696
- Yang M, et al. NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer. J Immunother Cancer. 2024;12(7):e009281. PMID: 39067875 | DOI: 10.1136/jitc-2024-009281
