Description
Senolytic peptide that disrupts FOXO4-p53 interaction
FOXO4-DRI is a synthetic peptide designed to selectively disrupt the interaction between FOXO4 and p53, thereby promoting the clearance of senescent cells and supporting tissue rejuvenation. Functions by modulating key transcriptional pathways involved in cellular stress response and apoptosis. Plays a significant role in influencing cellular homeostasis by encouraging the removal of dysfunctional cells. May improve tissue repair, reduce pro-inflammatory signaling, and enhance resilience against age-associated degenerative processes.
- Bourgeois B, et al. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI. Nat Commun. 2025;16(1):5672. PMID: 40593617 | DOI: 10.1038/s41467-025-60844-9
- Kong YX, et al. FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation. Commun Biol. 2025;8(1):299. PMID: 39994346 | DOI: 10.1038/s42003-025-07738-0
- Born E, et al. Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression. Circulation. 2023;147(8):650-666. PMID: 36515093 | DOI: 10.1161/CIRCULATIONAHA.122.058794
