Description
Reproductive neuropeptide that stimulates gonadotropin release
Kisspeptin is a naturally occurring peptide that plays a key role in regulating reproductive function by triggering the release of gonadotropin-releasing hormone (GnRH). Instrumental in initiating the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Published literature has also pointed to Kisspeptin’s influence on mood, emotional regulation, and stress response. Beyond reproductive effects, investigated for its potential role in supporting metabolic health and weight regulation.
References
- Mills EG, et al. Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans. EBioMedicine. 2025;115:105689. PMID: 40215751 | DOI: 10.1016/j.ebiom.2025.105689
- Navarro VM. Metabolic regulation of kisspeptin – the link between energy balance and reproduction. Nat Rev Endocrinol. 2020;16(8):407-420. PMID: 32427949 | DOI: 10.1038/s41574-020-0363-7
- Abreu AP, Kaiser UB. Pubertal development and regulation. Lancet Diabetes Endocrinol. 2016;4(3):254-264. PMID: 26852256 | DOI: 10.1016/S2213-8587(15)00418-0
Note: Kisspeptin-10 and kisspeptin-54 share the same active C-terminal decapeptide; the human data above span the directly relevant kisspeptin literature.
