Description
p53-derived anticancer peptide targeting membrane HDM-2
- Sarafraz-Yazdi E, et al. Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes. Proc Natl Acad Sci USA. 2010;107(5):1918-1923. PMID: 20080680 | DOI: 10.1073/pnas.0909364107
- Sarafraz-Yazdi E, et al. PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines. 2022;10(5):945. PMID: 35625682 | DOI: 10.3390/biomedicines10050945
- Thadi A, et al. Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells. Anticancer Res. 2020;40(9):4857-4867. PMID: 32878773 | DOI: 10.21873/anticanres.14488
